Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide

GeneMGI:97525Synonyms: r, rd10, +3 more

Physiological systems

23 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Respiratory system Hematopoietic system Behavior/neurological

18 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

4Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased blood uric acid level	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	2.61x10^-9
increased cellular hemoglobin content	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	5.73x10^-6
decreased body temperature	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	3.62x10^-5
decreased body weight	4 supporting datasets	Pde6b^Pde6b	homozygote	Early adult	3.56x10^-6
increased circulating potassium level	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	2.28x10^-6
abnormal whole-body plethysmography	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	1x10^-5
increased mean corpuscular volume	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	2.72x10^-7
decreased circulating amylase level	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	2.14x10^-7
decreased circulating triglyceride level	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	2.5x10^-8
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Pde6b^Pde6b	homozygote	Early adult	9.07x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pde6b.

Associated images

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Histopathology

There is no histopathology data found for Pde6b.

IMPC related publications

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External links

No external links available for Pde6b.

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*Pde6b^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pde6b^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pde6b^{tm44764(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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