Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Physiological systems
23 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Respiratory system Hematopoietic system Behavior/neurological
18 No significant impact
1 Not tested
Data collections
Gene metrics:13Significant phenotypes
4Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| increased blood uric acid level | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 2.61x10-9 | ||
| increased cellular hemoglobin content | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 5.73x10-6 | ||
| decreased body temperature | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 3.62x10-5 | ||
| decreased body weight | 4 supporting datasets | Pde6bPde6b | homozygote | Early adult | 3.56x10-6 | ||
| increased circulating potassium level | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 2.28x10-6 | ||
| abnormal whole-body plethysmography | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 1x10-5 | ||
| increased mean corpuscular volume | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 2.72x10-7 | ||
| decreased circulating amylase level | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 2.14x10-7 | ||
| decreased circulating triglyceride level | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 2.5x10-8 | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Pde6bPde6b | homozygote | Early adult | 9.07x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Pde6b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pde6b.
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| Pde6btm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pde6btm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pde6btm44764(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |