Pcx | pyruvate carboxylase
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging
13 No significant impact
5 Not tested
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:70Adult tissues
42Embryo tissues
| decreased bone mineral content | 1 supporting dataset | Pcxtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 8.7x10-5 | ||
| decreased lean body mass | 2 supporting datasets | Pcxtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.92x10-9 | ||
| increased total body fat amount | 2 supporting datasets | Pcxtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.09x10-9 | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Pcxtm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased respiratory quotient | 1 supporting dataset | Pcxtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.71x10-5 | ||
| increased grip strength | 1 supporting dataset | Pcxtm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.01x10-9 |
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External links
No external links available for Pcx.
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| Pcxtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | es cell |
| Pcxtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Pcxtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |