Pcsk4 | proprotein convertase subtilisin/kexin type 4

GeneMGI:97514Synonyms: PC4, SPC5

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Cardiovascular system

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

0Associated diseases

Expression examined in:52Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased heart weight	1 supporting dataset	Pcsk4^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.21x10^-8
increased circulating sodium level	1 supporting dataset	Pcsk4^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.38x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pcsk4.

Associated images

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Histopathology

There is no histopathology data found for Pcsk4.

IMPC related publications

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External links

No external links available for Pcsk4.

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*Pcsk4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pcsk4^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pcsk4^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Pcsk4^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pcsk4^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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