Pcsk2 | proprotein convertase subtilisin/kexin type 2

GeneMGI:97512Synonyms: SPC2, Nec-2, +5 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating glucose level	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	8.05x10^-8
increased circulating alanine transaminase level	1 supporting dataset	Pcsk2^em1(IMPC)H	heterozygote	Early adult	3.46x10^-12
limb grasping	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	5.69x10^-7
abnormal coat/ hair morphology	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	4.29x10^-5
increased circulating iron level	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	0
increased circulating cholesterol level	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	4.3x10^-9
increased mean corpuscular volume	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	1.61x10^-6
abnormal locomotor behavior	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	4.19x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	1.42x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Pcsk2^em1(IMPC)H	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Pcsk2.

Associated images

Loading...

Histopathology

There is no histopathology data found for Pcsk2.

IMPC related publications

Loading...

External links

No external links available for Pcsk2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Pcsk2^em1(IMPC)H*	Exon Deletion	‌	mouse
*Pcsk2^em2(IMPC)H*	Exon Deletion	‌	mouse
*Pcsk2^{tm28831(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes