Pbx3 | pre B cell leukemia homeobox 3

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Behavior/neurological Skeleton Craniofacial Mortality/aging

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



absent ovary	1 supporting dataset	Pbx3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal response to new environment	1 supporting dataset	Pbx3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.94x10^-5
abnormal tooth morphology	1 supporting dataset	Pbx3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.5x10^-7
increased total body fat amount	1 supporting dataset	Pbx3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.06x10^-6
decreased blood urea nitrogen level	1 supporting dataset	Pbx3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.7x10^-5
increased bone mineral content	1 supporting dataset	Pbx3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.27x10^-8
increased bone mineral density	1 supporting dataset	Pbx3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.02x10^-5
abnormal bone mineralization	1 supporting dataset	Pbx3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.78x10^-5
decreased total body fat amount	1 supporting dataset	Pbx3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.19x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Pbx3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pbx3.

Associated images

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Histopathology

There is no histopathology data found for Pbx3.

IMPC related publications

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External links

No external links available for Pbx3.

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*Pbx3^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Pbx3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pbx3^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pbx3^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell

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