Pax6 | paired box 6

GeneMGI:97490Synonyms: Gsfaey11, Pax-6, +4 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Embryo Growth/size/body region Digestive/alimentary Nervous system Vision/eye Liver/biliary system Behavior/neurological Craniofacial Cardiovascular system Mortality/aging

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

20Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal placenta vasculature	1 supporting dataset	Pax6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
anophthalmia	1 supporting dataset	Pax6^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal eye morphology	2 supporting datasets	Pax6^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Pax6^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
cleft palate	1 supporting dataset	Pax6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
anophthalmia	1 supporting dataset	Pax6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
hyperactivity	4 supporting datasets	Pax6^em1(IMPC)Mbp	heterozygote	Early adult	1.53x10^-5
microphthalmia	2 supporting datasets	Pax6^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
facial cleft	1 supporting dataset	Pax6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
decreased body length	1 supporting dataset	Pax6^em1(IMPC)Mbp	heterozygote	Early adult	7.73x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pax6.

Associated images

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Histopathology

There is no histopathology data found for Pax6.

IMPC related publications

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External links

No external links available for Pax6.

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*Pax6^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Pax6^{tm119340(pL1L2_GT1_DelLacZ_bsd)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Pax6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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