Pax5 | paired box 5
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Mortality/aging
14 No significant impact
4 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| impaired glucose tolerance | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.67x10-5 | ||
| increased circulating lipase level | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.04x10-5 | ||
| increased memory-marker CD4-positive NK T cell number | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.63x10-6 | ||
| decreased leukocyte cell number | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.81x10-6 | ||
| hyperactivity | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.93x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.95x10-5 | ||
| increased circulating amylase level | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.26x10-5 | ||
| immune system phenotype | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.36x10-5 | ||
| increased CD4-positive NK T cell number | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.3x10-5 | ||
| increased circulating triglyceride level | 1 supporting dataset | Pax5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.61x10-6 |
| | | | | | | | | | |
Human diseases caused by Pax5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pax5.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Pax5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pax5tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pax5tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |