Pax5 | paired box 5

GeneMGI:97489Synonyms: EBB-1, Pax-5

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



impaired glucose tolerance	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.67x10^-5
increased circulating lipase level	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.04x10^-5
increased memory-marker CD4-positive NK T cell number	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.63x10^-6
decreased leukocyte cell number	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.81x10^-6
hyperactivity	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.93x10^-5
abnormal auditory brainstem response	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.95x10^-5
increased circulating amylase level	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.26x10^-5
immune system phenotype	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.36x10^-5
increased CD4-positive NK T cell number	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.3x10^-5
increased circulating triglyceride level	1 supporting dataset	Pax5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.61x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pax5.

Associated images

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Histopathology

There is no histopathology data found for Pax5.

IMPC related publications

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External links

No external links available for Pax5.

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*Pax5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pax5^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pax5^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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