Ntrk1 | neurotrophic tyrosine kinase, receptor, type 1

GeneMGI:97383Synonyms: TrkA, Tkr

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Immune system Hematopoietic system Mortality/aging

16 No significant impact

5 Not tested

Gene metrics:2Significant phenotypes
5Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetNtrk1tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased basophil cell number1 supporting datasetNtrk1tm1b(EUCOMM)WtsiheterozygoteEarly adult7.83x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ntrk1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Ntrk1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Ntrk1tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Ntrk1tm1c(EUCOMM)WtsiWild type floxed exon (post-Flp)mouse
Ntrk1tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell
Ntrk1tm1e(EUCOMM)WtsiTargeted, non-conditional allelees cell
Ntrk1tm2(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)es cell
Ntrk1tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell

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