Nras | neuroblastoma ras oncogene

GeneMGI:97376Synonyms: N-ras

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Limbs/digits/tail Skeleton Mortality/aging

15 No significant impact

5 Not tested

Gene metrics:4Significant phenotypes
15Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetNrastm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased circulating glucose level1 supporting datasetNrastm1b(EUCOMM)HmguheterozygoteEarly adult6.46x10-6 
increased circulating HDL cholesterol level1 supporting datasetNrastm1b(EUCOMM)HmguheterozygoteEarly adult8.48x10-5 
short tibia1 supporting datasetNrastm1b(EUCOMM)HmguheterozygoteEarly adult1.79x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a100% (2/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
esophagusheterozygoten/a100% (2/2)1.67% (7/419)
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Human diseases caused by Nras mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Nrastm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Nrastm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Nrastm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Nrastm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Nrastm373486(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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