Nras | neuroblastoma ras oncogene
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Skeleton Mortality/aging
15 No significant impact
5 Not tested
Gene metrics:4Significant phenotypes
15Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Nrastm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating glucose level | 1 supporting dataset | Nrastm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.46x10-6 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Nrastm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.48x10-5 | ||
| short tibia | 1 supporting dataset | Nrastm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.79x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Nras mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nras.
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| Nrastm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Nrastm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nrastm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Nrastm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Nrastm373486(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |