Enpp1 | ectonucleotide pyrophosphatase/phosphodiesterase 1

GeneMGI:97370Synonyms: Ly-41, Pca, +9 more

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Limbs/digits/tail Respiratory system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:30Significant phenotypes

9Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased airway resistance	3 supporting datasets	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.89x10^-10
abnormal vertebrae morphology	1 supporting dataset	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	8.58x10^-15
abnormal scapula morphology	1 supporting dataset	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.82x10^-20
abnormal skin coloration	2 supporting datasets	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.92x10^-11
abnormal startle reflex	1 supporting dataset	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.32x10^-6
abnormal gait	1 supporting dataset	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.68x10^-13
decreased body weight	1 supporting dataset	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.42x10^-6
enlarged spleen	1 supporting dataset	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal sinus arrhythmia	1 supporting dataset	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.35x10^-9
vertebral fusion	1 supporting dataset	Enpp1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.39x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Enpp1.

Associated images

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Histopathology

There is no histopathology data found for Enpp1.

IMPC related publications

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External links

No external links available for Enpp1.

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*Enpp1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Enpp1^{tm380784(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
	KO first allele (reporter-tagged insertion with conditional potential)	‌	es cell

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