Nodal | nodal growth differentiation factor

GeneMGI:97359Synonyms: Tg.413d

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

9Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



abnormal startle reflex	1 supporting dataset	Nodal^tm1Rob	heterozygote	Early adult	8.58x10^-5
increased grip strength	4 supporting datasets	Nodal^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.09x10^-8
increased circulating cholesterol level	1 supporting dataset	Nodal^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.65x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Nodal^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Nodal^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.01x10^-6
cornea vascularization	1 supporting dataset	Nodal^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.22x10^-6
decreased locomotor activity	2 supporting datasets	Nodal^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.39x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Nodal^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Nodal^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.7x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Nodal^tm1Rob	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nodal.

Associated images

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Histopathology

There is no histopathology data found for Nodal.

IMPC related publications

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External links

No external links available for Nodal.

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*Nodal^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Nodal^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nodal^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nodal^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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