Nodal | nodal growth differentiation factor
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging Cardiovascular system
15 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
9Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| abnormal startle reflex | 1 supporting dataset | Nodaltm1Rob | heterozygote | Early adult | 8.58x10-5 | ||
| increased grip strength | 4 supporting datasets | Nodaltm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.09x10-8 | ||
| increased circulating cholesterol level | 1 supporting dataset | Nodaltm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.65x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Nodaltm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| increased circulating triglyceride level | 1 supporting dataset | Nodaltm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.01x10-6 | ||
| cornea vascularization | 1 supporting dataset | Nodaltm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.22x10-6 | ||
| decreased locomotor activity | 2 supporting datasets | Nodaltm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.39x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Nodaltm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Nodaltm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.7x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Nodaltm1Rob | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Nodal mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nodal.
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| Nodaltm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Nodaltm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nodaltm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Nodaltm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |