Nhlh2 | nescient helix loop helix 2

GeneMGI:97324Synonyms: Hen2, 6230401I09Rik, +3 more

Physiological systems

21 / 24 physiological systems tested

13 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging Renal/urinary system

8 No significant impact

3 Not tested

Gene metrics:29Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

absent ovary1 supporting datasetNhlh2tm1b(KOMP)MbphomozygoteEarly adultN/A * 
abnormal urinary bladder morphology1 supporting datasetNhlh2em1(IMPC)MbphomozygoteEarly adultN/A * 
absent testes1 supporting datasetNhlh2tm1b(KOMP)MbphomozygoteEarly adultN/A * 
abnormal epididymis morphology1 supporting datasetNhlh2tm1b(KOMP)MbphomozygoteEarly adultN/A * 
absent epididymis1 supporting datasetNhlh2tm1b(KOMP)MbphomozygoteEarly adultN/A * 
decreased bone mineral content2 supporting datasetsNhlh2tm1b(KOMP)MbphomozygoteEarly adult2.24x10-17 
abnormal cholesterol homeostasis1 supporting datasetNhlh2tm1b(KOMP)MbphomozygoteEarly adult1.21x10-8 
small uterus1 supporting datasetNhlh2tm1b(KOMP)MbphomozygoteEarly adultN/A * 
decreased lean body mass2 supporting datasetsNhlh2tm1b(KOMP)MbphomozygoteEarly adult9.13x10-8 
preweaning lethality, incomplete penetrance1 supporting datasetNhlh2tm1b(KOMP)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Nhlh2em1(IMPC)MbpIndelmouse
Nhlh2tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
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Nhlh2tm1b(KOMP)MbpReporter-tagged deletion allele (with selection cassette)mouse
Nhlh2tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell

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