Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

GeneMGI:97312Synonyms: p50/p105, p50, +5 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Vision/eye Hematopoietic system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating LDL cholesterol level	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.45x10^-7
increased circulating iron level	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.38x10^-5
decreased circulating sodium level	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.87x10^-7
decreased mean corpuscular hemoglobin	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.74x10^-7
abnormal cornea morphology	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.05x10^-8
increased circulating alkaline phosphatase level	2 supporting datasets	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.86x10^-5
abnormal skin condition	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.02x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.32x10^-5
decreased circulating serum albumin level	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.58x10^-5
increased circulating free fatty acids level	1 supporting dataset	Nfkb1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.38x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nfkb1.

Associated images

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Histopathology

There is no histopathology data found for Nfkb1.

IMPC related publications

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External links

No external links available for Nfkb1.

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*Nfkb1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nfkb1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Nfkb1^{tm272628(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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