Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Pigmentation Integument Vision/eye Hematopoietic system
15 No significant impact
3 Not tested
Data collections
Gene metrics:14Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased circulating LDL cholesterol level | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.45x10-7 | ||
| increased circulating iron level | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.38x10-5 | ||
| decreased circulating sodium level | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 5.87x10-7 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 8.74x10-7 | ||
| abnormal cornea morphology | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.05x10-8 | ||
| increased circulating alkaline phosphatase level | 2 supporting datasets | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.86x10-5 | ||
| abnormal skin condition | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 2.02x10-5 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 9.32x10-5 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 6.58x10-5 | ||
| increased circulating free fatty acids level | 1 supporting dataset | Nfkb1tm1a(KOMP)Wtsi | homozygote | Early adult | 5.38x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (1/1) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Nfkb1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Nfkb1.
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| Nfkb1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nfkb1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Nfkb1tm272628(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |