Nedd4 | neural precursor cell expressed, developmentally down-regulated 4

GeneMGI:97297Synonyms: E430025J12Rik, Nedd4-1, +2 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



impaired glucose tolerance	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	6.15x10^-7
abnormal behavior	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	3.67x10^-5
abnormal gait	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	6.29x10^-10
decreased thigmotaxis	2 supporting datasets	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	3.67x10^-5
increased lymphocyte cell number	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	5.67x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased locomotor activity	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.88x10^-5
increased grip strength	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	5.23x10^-5
increased leukocyte cell number	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	2.91x10^-5
decreased circulating creatinine level	1 supporting dataset	Nedd4^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.26x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nedd4.

Associated images

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Histopathology

There is no histopathology data found for Nedd4.

IMPC related publications

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External links

No external links available for Nedd4.

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*Nedd4^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Nedd4^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nedd4^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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