Ncf2 | neutrophil cytosolic factor 2

GeneMGI:97284Synonyms: NADPH oxidase subunit (67kDa), Ncf-2, +2 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Obsolete decreased cd4-positive, alpha beta t cell number Hematopoietic system Behavior/neurological Obsolete decreased cd8-positive, alpha beta t cell number

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



obsolete decreased CD8-positive, alpha beta T cell number	2 supporting datasets	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive NK cell number	4 supporting datasets	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased NK T cell number	4 supporting datasets	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased regulatory T cell number	2 supporting datasets	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.6x10^-5
decreased circulating thyroxine level	1 supporting dataset	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.63x10^-5
decreased T cell number	2 supporting datasets	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
obsolete decreased CD4-positive, alpha beta T cell number	2 supporting datasets	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased NK cell number	4 supporting datasets	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased grip strength	2 supporting datasets	Ncf2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.9x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ncf2.

Associated images

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Histopathology

There is no histopathology data found for Ncf2.

IMPC related publications

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External links

No external links available for Ncf2.

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*Ncf2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Ncf2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ncf2^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Ncf2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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