Ncam2 | neural cell adhesion molecule 2

GeneMGI:97282Synonyms: RNCAM, R4B12 antigen, +2 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Muscle Nervous system Hematopoietic system Behavior/neurological Cardiovascular system

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Ncam2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.9x10^-5
decreased exploration in new environment	1 supporting dataset	Ncam2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.64x10^-6
dilated heart left ventricle	1 supporting dataset	Ncam2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.28x10^-5
decreased cardiac muscle contractility	1 supporting dataset	Ncam2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.17x10^-5
increased eosinophil cell number	1 supporting dataset	Ncam2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.17x10^-6
decreased prepulse inhibition	1 supporting dataset	Ncam2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.73x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ncam2.

Associated images

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Histopathology

There is no histopathology data found for Ncam2.

IMPC related publications

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External links

No external links available for Ncam2.

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*Ncam2^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Ncam2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ncam2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ncam2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Ncam2^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ncam2^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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