Myc | myelocytomatosis oncogene

GeneMGI:97250Synonyms: Niard, c-myc, +3 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Behavior/neurological Skeleton Mortality/aging

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased startle reflex	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	3.3x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	homozygote	Early adult	N/A ^*
short tibia	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	3.47x10^-6
increased total body fat amount	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	4.01x10^-5
decreased bone mineral density	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	2.39x10^-5
decreased bone mineral content	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	1.2x10^-5
decreased fluid intake	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	8.39x10^-6
abnormal bone structure	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	2.59x10^-5
decreased body length	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	7x10^-15
decreased prepulse inhibition	1 supporting dataset	Myc^{em1(IMPC)Kmpc}	heterozygote	Early adult	9.28x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Myc.

Associated images

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Histopathology

There is no histopathology data found for Myc.

IMPC related publications

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External links

No external links available for Myc.

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*Myc^{em1(IMPC)Kmpc}*	Deletion	‌	mouse
*Myc^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Myc^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Myc^{tm91614(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Myc^{tm91614(pL1L2_GT0_DelLacZ_bsd)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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