Myb | myeloblastosis oncogene
Physiological systems
23 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Nervous system Mortality/aging Cardiovascular system
17 No significant impact
1 Not tested
Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:73Adult tissues
73Embryo tissues
| spina bifida | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| abnormal skin appearance | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| pallor | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| edema | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Mybtm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| hemorrhage | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | heterozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Mybtm1b(KOMP)Wtsi | heterozygote | E15.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
Human diseases caused by Myb mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Myb.
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| Mybtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mybtm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mybtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |