Mpl | myeloproliferative leukemia virus oncogene
Physiological systems
22 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Integument Growth/size/body region Respiratory system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
13 No significant impact
2 Not tested
Data collections
Gene metrics:9Significant phenotypes
9Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal vocalization | 1 supporting dataset | Mplem1(IMPC)Ccpcz | heterozygote | Early adult | 2.27x10-7 | ||
| abnormal skin morphology | 1 supporting dataset | Mplem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Mplem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal bone marrow morphology | 1 supporting dataset | Mplem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased airway resistance | 3 supporting datasets | Mplem1(IMPC)Ccpcz | heterozygote | Early adult | 6.2x10-16 | ||
| abnormal heart left ventricle morphology | 2 supporting datasets | Mplem1(IMPC)Ccpcz | heterozygote | Early adult | 2.88x10-5 | ||
| enlarged thymus | 1 supporting dataset | Mplem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Mplem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Mplem1(IMPC)Ccpcz | heterozygote | Early adult | N/A * |
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External links
No external links available for Mpl.
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| Mplem1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Mpltm240480(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |