Mpi | mannose phosphate isomerase
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Skeleton Mortality/aging
16 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating calcium level | 1 supporting dataset | Mpitm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.58x10-6 | ||
| increased prepulse inhibition | 1 supporting dataset | Mpitm1a(EUCOMM)Wtsi | heterozygote | Early adult | 9.69x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mpitm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal bone mineralization | 1 supporting dataset | Mpitm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.57x10-5 |
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Human diseases caused by Mpi mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mpi.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Mpitm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Mpitm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mpitm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |