Mdh1 | malate dehydrogenase 1, NAD (soluble)

GeneMGI:97051Synonyms: MDH-s, B230377B03Rik, +2 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Embryo Behavior/neurological Mortality/aging Cardiovascular system Craniofacial

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



thick ventricular wall	1 supporting dataset	Mdh1^em1(IMPC)Bay	heterozygote	Early adult	8.76x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Mdh1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Mdh1^em1(IMPC)Bay	homozygote	E12.5	N/A ^*
abnormal pharyngeal arch morphology	1 supporting dataset	Mdh1^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
decreased exploration in new environment	1 supporting dataset	Mdh1^em1(IMPC)Bay	heterozygote	Early adult	1.55x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mdh1.

Associated images

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Histopathology

There is no histopathology data found for Mdh1.

IMPC related publications

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External links

No external links available for Mdh1.

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*Mdh1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Mdh1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Mdh1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Mdh1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Mdh1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Mdh1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Mdh1^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Mdh1^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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