Mmp2 | matrix metallopeptidase 2

GeneMGI:97009Synonyms: gelatinase A, GelA, +4 more

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

 Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Nervous system Vision/eye Hematopoietic system Skeleton Cardiovascular system Renal/urinary system

9 No significant impact

3 Not tested

Gene metrics:19Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal bone structure1 supporting datasetMmp2em1(IMPC)MbphomozygoteEarly adult1.13x10-10 
abnormal seminal vesicle morphology1 supporting datasetMmp2em1(IMPC)MbphomozygoteLate adultN/A * 
decreased prepulse inhibition2 supporting datasetsMmp2em1(IMPC)MbphomozygoteEarly adult3.97x10-5 
abnormal spleen morphology1 supporting datasetMmp2em1(IMPC)MbphomozygoteLate adultN/A * 
enlarged stomach1 supporting datasetMmp2em1(IMPC)MbphomozygoteLate adultN/A * 
abnormal kidney morphology1 supporting datasetMmp2em1(IMPC)MbphomozygoteEarly adultN/A * 
increased heart rate1 supporting datasetMmp2em1(IMPC)MbphomozygoteLate adult7.33x10-5 
abnormal skin morphology1 supporting datasetMmp2em1(IMPC)MbphomozygoteEarly adultN/A * 
enlarged spleen1 supporting datasetMmp2em1(IMPC)MbphomozygoteLate adultN/A * 
enlarged lymph nodes1 supporting datasetMmp2em1(IMPC)MbphomozygoteLate adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mmp2em1(IMPC)MbpExon Deletionmouse

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