Mmp11 | matrix metallopeptidase 11

GeneMGI:97008Synonyms: ST3, Stmy3, +1 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Cardiovascular system Mortality/aging

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



decreased mean corpuscular hemoglobin	1 supporting dataset	Mmp11^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.42x10^-5
increased monocyte cell number	2 supporting datasets	Mmp11^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.79x10^-11
abnormal tail morphology	1 supporting dataset	Mmp11^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.04x10^-6
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Mmp11^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.84x10^-5
increased heart weight	1 supporting dataset	Mmp11^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	2.76x10^-5
decreased circulating serum albumin level	1 supporting dataset	Mmp11^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.38x10^-5
abnormal skin coloration	1 supporting dataset	Mmp11^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.03x10^-19
decreased total retina thickness	1 supporting dataset	Mmp11^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.51x10^-5
abnormal heart morphology	1 supporting dataset	Mmp11^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	1.88x10^-7
decreased circulating triglyceride level	1 supporting dataset	Mmp11^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	1.09x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mmp11.

Associated images

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Histopathology

There is no histopathology data found for Mmp11.

IMPC related publications

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External links

No external links available for Mmp11.

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*Mmp11^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Mmp11^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mmp11^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mmp11^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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