Kmt2a | lysine (K)-specific methyltransferase 2A

GeneMGI:96995Synonyms: All1, Mll, +5 more

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Growth/size/body region Vision/eye Skeleton Mortality/aging Cardiovascular system

11 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased bone mineral density	1 supporting dataset	Kmt2a^{em1(IMPC)Marc}	heterozygote	Early adult	2.13x10^-5
abnormal retina morphology	1 supporting dataset	Kmt2a^{em1(IMPC)Marc}	heterozygote	Early adult	2.47x10^-6
increased heart rate	1 supporting dataset	Kmt2a^{em1(IMPC)Marc}	heterozygote	Early adult	2.95x10^-6
increased lean body mass	1 supporting dataset	Kmt2a^{em1(IMPC)Marc}	heterozygote	Early adult	2.93x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Kmt2a^{em1(IMPC)Marc}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Kmt2a.

Associated images

Loading...

Histopathology

There is no histopathology data found for Kmt2a.

IMPC related publications

Loading...

External links

No external links available for Kmt2a.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Kmt2a^{em1(IMPC)Marc}*	Deletion	‌	mouse
*Kmt2a^{tm40303(L1L2_gt0_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Kmt2a^{tm40303(pL1L2_frt15_BetactinBSD_frt14_neo_Rox)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes