Mgmt | O-6-methylguanine-DNA methyltransferase

GeneMGI:96977Synonyms: Agat, AGT

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased prepulse inhibition	2 supporting datasets	Mgmt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.9x10^-6
increased blood urea nitrogen level	1 supporting dataset	Mgmt^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.44x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mgmt.

Associated images

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Histopathology

There is no histopathology data found for Mgmt.

IMPC related publications

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External links

No external links available for Mgmt.

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*Mgmt^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mgmt^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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