Mc3r | melanocortin 3 receptor

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Skeleton Cardiovascular system Renal/urinary system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small kidney	1 supporting dataset	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased lean body mass	2 supporting datasets	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	5.28x10^-13
increased total body fat amount	2 supporting datasets	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	3.9x10^-13
abnormal skin morphology	1 supporting dataset	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased bone mineral content	2 supporting datasets	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	1.76x10^-11
small testis	1 supporting dataset	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased heart weight	2 supporting datasets	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	4.14x10^-5
abnormal kidney morphology	1 supporting dataset	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Mc3r^em1(IMPC)Mbp	homozygote	Early adult	6.04x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mc3r.

Associated images

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Histopathology

There is no histopathology data found for Mc3r.

IMPC related publications

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External links

No external links available for Mc3r.

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*Mc3r^em1(IMPC)Mbp*	Whole-gene deletion	‌	mouse
*Mc3r^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Mc3r^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mc3r^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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