Lyn | LYN proto-oncogene, Src family tyrosine kinase
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial
11 No significant impact
4 Not tested
Data collections
Gene metrics:24Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased lymphocyte cell number | 2 supporting datasets | Lyntm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.87x10-28 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Late adult | 3.73x10-11 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.07x10-6 | ||
| decreased leukocyte cell number | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.74x10-14 | ||
| decreased hematocrit | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Late adult | 5.14x10-14 | ||
| increased spleen weight | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.18x10-21 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Late adult | 9.99x10-8 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Late adult | 4.34x10-5 | ||
| thrombocytopenia | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Late adult | 1.19x10-11 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Lyntm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.27x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Lyn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Lyn.
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| Lyntm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Lyntm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Lyntm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Lyntm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |