Lyn | LYN proto-oncogene, Src family tyrosine kinase

GeneMGI:96892Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:24Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased lymphocyte cell number	2 supporting datasets	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.87x10^-28
decreased erythrocyte cell number	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	3.73x10^-11
increased blood urea nitrogen level	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.07x10^-6
decreased leukocyte cell number	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.74x10^-14
decreased hematocrit	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	5.14x10^-14
increased spleen weight	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.18x10^-21
increased blood urea nitrogen level	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	9.99x10^-8
decreased circulating HDL cholesterol level	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	4.34x10^-5
thrombocytopenia	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	1.19x10^-11
decreased erythrocyte cell number	1 supporting dataset	Lyn^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.27x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lyn.

Associated images

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Histopathology

There is no histopathology data found for Lyn.

IMPC related publications

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External links

No external links available for Lyn.

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*Lyn^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Lyn^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Lyn^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lyn^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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