Blnk | B cell linker

GeneMGI:96878Synonyms: Ly57, BLNK, +5 more

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Immune system Hematopoietic system

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased spleen weight1 supporting datasetBlnkem1(IMPC)HhomozygoteEarly adult9.53x10-12 
decreased leukocyte cell number1 supporting datasetBlnkem1(IMPC)HhomozygoteEarly adult1.48x10-9 
decreased lymphocyte cell number2 supporting datasetsBlnkem1(IMPC)HhomozygoteEarly adult1.64x10-11 
increased eosinophil cell number1 supporting datasetBlnkem1(IMPC)HhomozygoteEarly adult2.13x10-12 
increased neutrophil cell number1 supporting datasetBlnkem1(IMPC)HhomozygoteEarly adult1.16x10-7 
small spleen2 supporting datasetsBlnkem1(IMPC)HhomozygoteEarly adultN/A * 
decreased basophil cell number1 supporting datasetBlnkem1(IMPC)HhomozygoteEarly adult2.44x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Blnkem1(IMPC)HExon Deletionmouse
Blnktm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Blnktm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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