Klrb1 | killer cell lectin-like receptor subfamily B member 1

GeneMGI:96877Synonyms: Ly55, Gm4696, +3 more

Physiological systems

23 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

13 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



increased grip strength	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	5.76x10^-5
abnormal kidney morphology	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	N/A ^*
increased follicular B cell number	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	4.7x10^-6
polycystic kidney	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	N/A ^*
decreased leukocyte cell number	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	7.75x10^-5
dilated aorta	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.78x10^-14
abnormal seminal vesicle morphology	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
enlarged cecum	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Klrb1^{tm1b(EUCOMM)Wtsi}	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Klrb1.

Associated images

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Histopathology

There is no histopathology data found for Klrb1.

IMPC related publications

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External links

No external links available for Klrb1.

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*Klrb1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Klrb1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Klrb1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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