Lipe | lipase, hormone sensitive
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Growth/size/body region Behavior/neurological Skeleton Renal/urinary system
15 No significant impact
3 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| hyperactivity | 4 supporting datasets | Lipetm1b(KOMP)Wtsi | homozygote | Early adult | 9.89x10-6 | ||
| increased circulating insulin level | 1 supporting dataset | Lipetm1b(KOMP)Wtsi | homozygote | Early adult | 7.73x10-7 | ||
| increased kidney weight | 1 supporting dataset | Lipetm1b(KOMP)Wtsi | homozygote | Early adult | 2.3x10-5 | ||
| increased bone mineral density | 1 supporting dataset | Lipetm1b(KOMP)Wtsi | homozygote | Early adult | 2.86x10-6 | ||
| male infertility | 1 supporting dataset | Lipetm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Lipe mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Lipe.
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| Lipetm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Lipetm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Lipetm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |