Ldha | lactate dehydrogenase A

GeneMGI:96759Synonyms: l7R2, lactate dehydrogenase-A, +3 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Skeleton Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased total body fat amount	1 supporting dataset	Ldha^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.4x10^-7
decreased body weight	2 supporting datasets	Ldha^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.57x10^-5
increased lean body mass	1 supporting dataset	Ldha^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.93x10^-8
increased body length	1 supporting dataset	Ldha^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.16x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Ldha^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral density	1 supporting dataset	Ldha^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.34x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ldha.

Associated images

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Histopathology

There is no histopathology data found for Ldha.

IMPC related publications

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External links

No external links available for Ldha.

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*Ldha^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ldha^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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