Krt17 | keratin 17
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Cardiovascular system
13 No significant impact
7 Not tested
Data collections
Gene metrics:4Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
51Embryo tissues
| increased hemoglobin content | 1 supporting dataset | Krt17tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.68x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Krt17tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.05x10-5 | ||
| increased heart weight | 1 supporting dataset | Krt17tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.88x10-7 | ||
| decreased hematocrit | 1 supporting dataset | Krt17tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.98x10-9 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Krt17 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Krt17.
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| Krt17tm1(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Krt17tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Krt17tm1.1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | ES Cell |
| Krt17tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Krt17tm112116(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Krt17tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Krt17tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Krt17tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |