Krt14 | keratin 14

GeneMGI:96688Synonyms: Cytokeratin 14, epidermolysis bullosa simplex, Dowling-Meara, Koebner, +3 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Embryo Growth/size/body region Digestive/alimentary Nervous system Vision/eye Craniofacial Cardiovascular system Mortality/aging

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

13Associated diseases

Expression examined in:73Adult tissues

34Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



microphthalmia	1 supporting dataset	Krt14^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
spina bifida	1 supporting dataset	Krt14^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
cleft palate	1 supporting dataset	Krt14^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Krt14^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Krt14^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Krt14^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
spina bifida	1 supporting dataset	Krt14^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Krt14^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	2 supporting datasets	Krt14^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Krt14.

Associated images

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Histopathology

There is no histopathology data found for Krt14.

IMPC related publications

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External links

No external links available for Krt14.

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*Krt14^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Krt14^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Krt14^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Krt14^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Krt14^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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