Krt14 | keratin 14
GeneMGI:96688Synonyms: Cytokeratin 14, epidermolysis bullosa simplex, Dowling-Meara, Koebner, +3 more
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Embryo Growth/size/body region Digestive/alimentary Nervous system Vision/eye Craniofacial Cardiovascular system Mortality/aging
12 No significant impact
4 Not tested
Gene metrics:7Significant phenotypes
13Associated diseases
Expression examined in:73Adult tissues
34Embryo tissues
| microphthalmia | 1 supporting dataset | Krt14tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Krt14tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| cleft palate | 1 supporting dataset | Krt14tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Krt14tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Krt14tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Krt14tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Krt14tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Krt14tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Krt14tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Krt14 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Krt14.
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| Krt14tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Krt14tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Krt14tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Krt14tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Krt14tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |