Kin | Kin17 DNA and RNA binding protein
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Mortality/aging Cardiovascular system
15 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Kinem1(IMPC)J | homozygote | Early adult | N/A * | ||
| decreased circulating calcium level | 1 supporting dataset | Kinem1(IMPC)J | heterozygote | Early adult | 3.74x10-5 | ||
| increased heart rate | 1 supporting dataset | Kinem1(IMPC)J | heterozygote | Early adult | 4.84x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Kinem1(IMPC)J | homozygote | E9.5 | N/A * | ||
| shortened RR interval | 1 supporting dataset | Kinem1(IMPC)J | heterozygote | Early adult | 4.24x10-5 |
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Human diseases caused by Kin mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Kin.
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| Kinem1(IMPC)J | Exon Deletion | | mouse |
| Kintm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Kintm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Kintm34030(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |