Kcnc3 | potassium voltage gated channel, Shaw-related subfamily, member 3

GeneMGI:96669Synonyms: KShIIID, Kv3.3, +1 more

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Behavior/neurological Skeleton

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased grip strength2 supporting datasetsKcnc3em1(IMPC)BayhomozygoteEarly adult7.24x10-7 
hyperactivity3 supporting datasetsKcnc3em1(IMPC)BayhomozygoteEarly adult4.94x10-6 
hyperactivity5 supporting datasetsKcnc3em1(IMPC)JhomozygoteEarly adult6.01x10-11 
hyperactivity7 supporting datasetsKcnc3em1(IMPC)JhomozygoteLate adult4.51x10-9 
decreased bone mineral content1 supporting datasetKcnc3em1(IMPC)JhomozygoteLate adult4.33x10-5 
abnormal sleep behavior1 supporting datasetKcnc3em1(IMPC)JhomozygoteEarly adult5.87x10-5 
increased vertical activity1 supporting datasetKcnc3em1(IMPC)JhomozygoteLate adult4.28x10-7 
decreased bone mineral density1 supporting datasetKcnc3em1(IMPC)JhomozygoteLate adult1.61x10-6 
decreased grip strength1 supporting datasetKcnc3em1(IMPC)JhomozygoteLate adult1.14x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Kcnc3em1(IMPC)BayExon Deletionmouse
Kcnc3em1(IMPC)JInter-exon deletionmouse
Kcnc3tm87170(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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