Jup | junction plakoglobin

GeneMGI:96650Synonyms: plakoglobin, Ctnng, +3 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

7Associated diseases

Expression examined in:49Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



impaired righting response	1 supporting dataset	Jup^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	9.64x10^-8
abnormal embryo size	1 supporting dataset	Jup^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Jup^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Jup^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased coping response	1 supporting dataset	Jup^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.54x10^-5
decreased fasting circulating glucose level	1 supporting dataset	Jup^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.95x10^-12
increased hemoglobin content	1 supporting dataset	Jup^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.58x10^-6
decreased circulating phosphate level	1 supporting dataset	Jup^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1x10^-4

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Jup.

Associated images

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Histopathology

There is no histopathology data found for Jup.

IMPC related publications

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External links

No external links available for Jup.

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*Jup^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Jup^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Jup^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Jup^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Jup^{tm33830(L1L2_gt2_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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