Junb | jun B proto-oncogene

GeneMGI:96647

Physiological systems

15 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Embryo Growth/size/body region Nervous system Hematopoietic system Mortality/aging

9 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:50Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic growth retardation	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal neural tube morphology	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal midbrain development	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal embryo turning	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal hindbrain development	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal forebrain development	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
increased spleen weight	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.66x10^-26
preweaning lethality, complete penetrance	3 supporting datasets	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Junb^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Junb.

Associated images

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Histopathology

There is no histopathology data found for Junb.

IMPC related publications

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External links

No external links available for Junb.

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*Junb^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Junb^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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