Itgb6 | integrin beta 6
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Vision/eye Respiratory system Hematopoietic system Skeleton Craniofacial
11 No significant impact
2 Not tested
Data collections
Gene metrics:15Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal tooth morphology | 3 supporting datasets | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | 0 | ||
| abnormal tooth color | 1 supporting dataset | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | 1.37x10-5 | ||
| abnormal eye morphology | 1 supporting dataset | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased lung elastance | 5 supporting datasets | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | 4.05x10-8 | ||
| decreased body weight | 2 supporting datasets | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | 1.1x10-7 | ||
| anophthalmia | 1 supporting dataset | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| decreased lung tissue damping | 1 supporting dataset | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | 1.69x10-5 | ||
| abnormal digit morphology | 2 supporting datasets | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | 1.22x10-10 | ||
| enlarged thymus | 2 supporting datasets | Itgb6em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Itgb6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Itgb6.
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| Itgb6em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Itgb6tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Itgb6tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |