Itgb6 | integrin beta 6

GeneMGI:96615Synonyms: 2210409C20Rik, 4831415H04Rik

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Vision/eye Respiratory system Hematopoietic system Skeleton Craniofacial

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal tooth morphology	3 supporting datasets	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	0
abnormal tooth color	1 supporting dataset	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.37x10^-5
abnormal eye morphology	1 supporting dataset	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased lung elastance	5 supporting datasets	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.05x10^-8
decreased body weight	2 supporting datasets	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.1x10^-7
anophthalmia	1 supporting dataset	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased lung tissue damping	1 supporting dataset	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.69x10^-5
abnormal digit morphology	2 supporting datasets	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.22x10^-10
enlarged thymus	2 supporting datasets	Itgb6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Itgb6.

Associated images

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Histopathology

There is no histopathology data found for Itgb6.

IMPC related publications

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External links

No external links available for Itgb6.

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*Itgb6^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Itgb6^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Itgb6^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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