Ins1 | insulin I

Physiological systems

15 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Behavior/neurological Cardiovascular system

13 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:3Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

thin ventricular wall1 supporting datasetIns1em1(IMPC)MarchomozygoteEarly adult1.44x10-5 
decreased grip strength1 supporting datasetIns1em1(IMPC)MarchomozygoteEarly adult2.06x10-5 
decreased exploration in new environment1 supporting datasetIns1em1(IMPC)MarchomozygoteEarly adult9.84x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ins1em1(IMPC)MarcDeletionmouse
Ins1tm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Ins1tm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Ins1tm2(EGFP/cre/ERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Ins1tm456604(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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