Il6st | interleukin 6 signal transducer
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
7Associated diseases
Expression examined in:50Adult tissues
50Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Il6sttm1b(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Il6sttm1b(KOMP)Mbp | homozygote | E12.5 | N/A * | ||
| increased circulating bilirubin level | 1 supporting dataset | Il6sttm1b(KOMP)Mbp | heterozygote | Early adult | 6.57x10-5 | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Il6sttm1b(KOMP)Mbp | heterozygote | Early adult | 4.89x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (4/4) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (4/4) | 0.19% (1/533) |
| bone | heterozygote | Section images | 100% (2/2) | 0% (0/394) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (4/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (4/4) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (4/4) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (4/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (4/4) | 0.41% (2/491) |
Human diseases caused by Il6st mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Il6st.
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| Il6sttm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Il6sttm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Il6sttm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Il6sttm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Il6sttm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |