Il2rb | interleukin 2 receptor, beta chain

GeneMGI:96550Synonyms: IL15Rbeta, IL-2/15Rbeta, +4 more

Physiological systems

8 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Reproductive system Integument Limbs/digits/tail Hearing/vestibular/ear

4 No significant impact

16 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat appearance3 supporting datasetsIl2rbtm1b(EUCOMM)HmguhomozygoteEarly adult1.81x10-7 
abnormal coat/ hair morphology3 supporting datasetsIl2rbtm1b(EUCOMM)HmguhomozygoteEarly adult1.81x10-7 
abnormal ear morphology1 supporting datasetIl2rbtm1b(EUCOMM)HmguhomozygoteEarly adult2.29x10-11 
male infertility1 supporting datasetIl2rbtm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
abnormal autopod morphology2 supporting datasetsIl2rbtm1b(EUCOMM)HmguhomozygoteEarly adult6.85x10-12 
female infertility1 supporting datasetIl2rbtm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Il2rbtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Il2rbtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Il2rbtm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Il2rbtm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Il2rbtm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Il2rbtm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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