Rbpj | recombination signal binding protein for immunoglobulin kappa J region

GeneMGI:96522Synonyms: RBPjk, Igkrsbp, +4 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Skeleton Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to tooth bud stage	1 supporting dataset	Rbpj^{tm1b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
increased circulating bilirubin level	1 supporting dataset	Rbpj^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.33x10^-7
decreased circulating HDL cholesterol level	1 supporting dataset	Rbpj^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.99x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Rbpj^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased grip strength	1 supporting dataset	Rbpj^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.27x10^-5
decreased bone mineral density	1 supporting dataset	Rbpj^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.26x10^-5
improved glucose tolerance	1 supporting dataset	Rbpj^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.19x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rbpj.

Associated images

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Histopathology

There is no histopathology data found for Rbpj.

IMPC related publications

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External links

No external links available for Rbpj.

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*Rbpj^em2H*	Point Mutation	‌	mouse
*Rbpj^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Rbpj^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Rbpj^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rbpj^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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