Idua | iduronidase, alpha-L
GeneMGI:96418
Physiological systems
20 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Immune system Integument Adipose tissue Growth/size/body region Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial
9 No significant impact
4 Not tested
Data collections
Gene metrics:14Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina vasculature morphology | 1 supporting dataset | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 1.27x10-5 | ||
| decreased grip strength | 4 supporting datasets | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 3.63x10-7 | ||
| abnormal startle reflex | 1 supporting dataset | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 1.04x10-5 | ||
| narrow eye opening | 1 supporting dataset | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 9.85x10-22 | ||
| abnormal auditory brainstem response | 4 supporting datasets | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 4.31x10-7 | ||
| decreased total retina thickness | 2 supporting datasets | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 4.43x10-30 | ||
| abnormal cornea morphology | 1 supporting dataset | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 7.99x10-7 | ||
| thick skin | 1 supporting dataset | Iduaem1(IMPC)Hmgu | homozygote | Early adult | N/A * | ||
| tremors | 1 supporting dataset | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 4.78x10-6 | ||
| increased spleen weight | 1 supporting dataset | Iduaem1(IMPC)Hmgu | homozygote | Early adult | 7.78x10-5 |
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Human diseases caused by Idua mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Idua.
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| Iduaem1(IMPC)Hmgu | Exon Deletion | | mouse |
| Iduatm271527(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |