Idua | iduronidase, alpha-L

Physiological systems

20 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Immune system Integument Adipose tissue Growth/size/body region Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial

9 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina vasculature morphology	1 supporting dataset	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	1.27x10^-5
decreased grip strength	4 supporting datasets	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	3.63x10^-7
abnormal startle reflex	1 supporting dataset	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	1.04x10^-5
narrow eye opening	1 supporting dataset	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	9.85x10^-22
abnormal auditory brainstem response	4 supporting datasets	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	4.31x10^-7
decreased total retina thickness	2 supporting datasets	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	4.43x10^-30
abnormal cornea morphology	1 supporting dataset	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	7.99x10^-7
thick skin	1 supporting dataset	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	N/A ^*
tremors	1 supporting dataset	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	4.78x10^-6
increased spleen weight	1 supporting dataset	Idua^{em1(IMPC)Hmgu}	homozygote	Early adult	7.78x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Idua.

Associated images

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Histopathology

There is no histopathology data found for Idua.

IMPC related publications

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External links

No external links available for Idua.

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*Idua^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Idua^{tm271527(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes