Idh2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial
Physiological systems
18 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Hematopoietic system
17 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
13Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Idh2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.44x10-6 | ||
| increased hemoglobin content | 1 supporting dataset | Idh2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.77x10-5 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Idh2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.01x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/1) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Idh2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Idh2.
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| Idh2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Idh2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Idh2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |