Ide | insulin degrading enzyme

GeneMGI:96412Synonyms: 1300012G03Rik, 4833415K22Rik

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Adipose tissue Growth/size/body region Skeleton Cardiovascular system Craniofacial

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal maxilla morphology	1 supporting dataset	Ide^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.54x10^-5
increased lean body mass	1 supporting dataset	Ide^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.71x10^-6
increased circulating amylase level	1 supporting dataset	Ide^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.81x10^-11
increased heart weight	1 supporting dataset	Ide^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.59x10^-9
decreased total body fat amount	1 supporting dataset	Ide^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.06x10^-5
abnormal incisor morphology	1 supporting dataset	Ide^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.73x10^-6
abnormal hair texture	1 supporting dataset	Ide^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.95x10^-6
abnormal cranium morphology	1 supporting dataset	Ide^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.34x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ide.

Associated images

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Histopathology

There is no histopathology data found for Ide.

IMPC related publications

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External links

No external links available for Ide.

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*Ide^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ide^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Ide^{tm47938(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ide^{tm47938(L1L2_gt2_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Ide^{tm47938(pL1L2_frt15_BetactinBSD_frt14_neo_Rox)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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