Id3 | inhibitor of DNA binding 3
Physiological systems
20 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
9 No significant impact
4 Not tested
Data collections
Gene metrics:21Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged spleen | 2 supporting datasets | Id3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased red blood cell distribution width | 1 supporting dataset | Id3em1(IMPC)Mbp | homozygote | Early adult | 2.79x10-5 | ||
| small testis | 1 supporting dataset | Id3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Id3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal freezing behavior | 1 supporting dataset | Id3em1(IMPC)Mbp | homozygote | Early adult | 4.67x10-5 | ||
| decreased brain size | 1 supporting dataset | Id3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| cornea opacity | 1 supporting dataset | Id3em1(IMPC)Mbp | homozygote | Early adult | 9.98x10-6 | ||
| increased startle reflex | 1 supporting dataset | Id3em1(IMPC)Mbp | homozygote | Early adult | 1.74x10-5 | ||
| microphthalmia | 2 supporting datasets | Id3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased mean platelet volume | 1 supporting dataset | Id3em1(IMPC)Mbp | homozygote | Early adult | 8.62x10-5 |
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Human diseases caused by Id3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Id3.
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| Id3em1(IMPC)Mbp | Whole-gene deletion | | mouse |
| Id3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Id3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Id3tm415703(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |