Ica1 | islet cell autoantigen 1

GeneMGI:96391Synonyms: 69kDa, ICA69

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Immune system Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Behavior/neurological Renal/urinary system

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	1 supporting dataset	Ica1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
enlarged cecum	2 supporting datasets	Ica1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Ica1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal cecum morphology	2 supporting datasets	Ica1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Ica1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Ica1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Ica1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased locomotor activity	2 supporting datasets	Ica1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.98x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ica1.

Associated images

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Histopathology

There is no histopathology data found for Ica1.

IMPC related publications

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External links

No external links available for Ica1.

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*Ica1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ica1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ica1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ica1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ica1^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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