Hr | lysine demethylase and nuclear receptor corepressor
Physiological systems
16 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Hematopoietic system
12 No significant impact
8 Not tested
Data collections
Gene metrics:9Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating HDL cholesterol level | 1 supporting dataset | Hrem1(IMPC)H | homozygote | Early adult | 1.19x10-10 | ||
| abnormal coat/ hair morphology | 3 supporting datasets | Hrem1(IMPC)H | homozygote | Early adult | 3.63x10-21 | ||
| increased neutrophil cell number | 2 supporting datasets | Hrem1(IMPC)H | homozygote | Early adult | 1.33x10-11 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Hrem1(IMPC)H | homozygote | Early adult | 4.34x10-8 | ||
| absent vibrissae | 1 supporting dataset | Hrem1(IMPC)H | homozygote | Early adult | 1.2x10-18 | ||
| abnormal vibrissa morphology | 1 supporting dataset | Hrem1(IMPC)H | homozygote | Early adult | 7.13x10-17 | ||
| decreased circulating alkaline phosphatase level | 1 supporting dataset | Hrem1(IMPC)H | homozygote | Early adult | 7.61x10-11 | ||
| decreased circulating amylase level | 1 supporting dataset | Hrem1(IMPC)H | homozygote | Early adult | 3.97x10-8 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Hrem1(IMPC)H | homozygote | Early adult | 2.11x10-12 |
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External links
No external links available for Hr.
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| Hrem1(IMPC)H | Exon Deletion | | mouse |
| Hrem2(IMPC)H | Exon Deletion | | mouse |
| Hrtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Hrtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |