Hmgn2 | high mobility group nucleosomal binding domain 2
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Embryo Growth/size/body region Mortality/aging
16 No significant impact
5 Not tested
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:41Adult tissues
52Embryo tissues
| abnormal embryo size | 1 supporting dataset | Hmgn2tm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Hmgn2tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (1/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
| eye | heterozygote | Section images | 100% (2/2) | 0% (0/335) |
| heart | heterozygote | Section images | 100% (2/2) | 0.36% (2/550) |
Human diseases caused by Hmgn2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Hmgn2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Hmgn2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Hmgn2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Hmgn2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |