Hmbs | hydroxymethylbilane synthase
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Behavior/neurological Mortality/aging
14 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| increased startle reflex | 1 supporting dataset | Hmbstm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.58x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Hmbstm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Hmbstm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| abnormal vitreous body morphology | 1 supporting dataset | Hmbstm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.4x10-6 | ||
| abnormal lens morphology | 1 supporting dataset | Hmbstm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.08x10-6 | ||
| hyperactivity | 1 supporting dataset | Hmbstm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.45x10-5 |
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External links
No external links available for Hmbs.
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| Hmbstm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Hmbstm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Hmbstm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |